NSD2 and Wolf-Hirschhorn syndrome: NSD2 is a critical gene in the pathology of Wolf–Hirschhorn Syndrome (WHS; Jiang et al., 2019; McDevitt et al., 2019), a severe neurodevelopmental disorder characterized by distinctive developmental delays (DDs), intellectual disabilities (IDs), and seizures, which occur in more than 50% of WHS infants (Deardorff and Zackai, 2007).