Besides that, the tumor cell lines SCC25 and Detroit 562 represent genetic changes encountered in EGFR/RAS/RAF/MEK/ERK and EGFR/PI3K/AKT/mTOR signaling (Supplementary materials) that play a pivotal role in cancer development and resistance (Ancrile et al., 2007). The gene discussed is AKT1; the disease is neoplasm.