TLR4 and meningeal tuberculosis: • Astrocyte-microglia lactate shuttle proposed for tuberculous meningitis (Mason et al., 2015)• CD147+ T cell populations enhanced by Mtb antigen stimulation (Feruglio et al., 2015)• MCT4 expression increased during Mtb infection and enhanced by TLR2 and TLR4 signaling (Shi et al., 2015; Tan et al., 2015; Vrieling et al., 2020)• MCT4 expressed in the phagosome compartment of mycobacteria infected macrophages (Lee et al., 2010)• Angiogenesis implicated in increased Mtb dissemination (Polena et al., 2016)