Further, lactate suppresses the induction of the NLRP3 inflammasome and IL1β via GPR81 activation, regulates TLR activation via interactions with arrestin B2 downstream of GPR81, and protects against inflammatory injury in pancreatitis and hepatitis models through GPR81 signaling (Hoque et al., 2014). The gene discussed is HCAR1; the disease is Hepatitis.