In some cancers, isoforms with only LDHA subunits have the highest efficiency at converting pyruvate to lactate and are correlated with increased HIF-1α and VEGF expression, increased tumor size, enhanced metastatic potential, and thus a poor prognosis (Koukourakis et al., 2003; Koukourakis et al., 2005; Kolev et al., 2008). This evidence concerns the gene HIF1A and cancer.