The research combining MCT inhibition and biguanides is of interest for TB therapy, as metformin has been actively explored as a HDT (Lin et al., 2018; Lachmandas et al., 2019; Oglesby et al., 2019; Yew et al., 2019; Abinaya et al., 2020; Frenkel et al., 2020; Rodriguez-Carlos et al., 2020). This evidence concerns the gene SLC16A1 and tuberculosis.