Accumulated lactate in the tumor microenvironment, which can reach up to 40 mM concentrations, decelerates energy metabolism and induces suppressed phenotypes in infiltrating T cells by decreasing antigen-specific proliferation, and impairing T cell production of IL-1, IFN-γ, perforin and granzyme B (Fischer et al., 2007; Choi et al., 2013). This evidence concerns the gene IFNG and neoplasm.