• Is MCT inhibition, either alone or in combination with other therapies, beneficial in the case of TB?• Would LDH inhibition work better in combination with other inhibitors for Mtb infection?• LDHA inhibition limits the ability for Mtb to use host lactate, but can lead to pyruvate accumulation, which is efficiently metabolized by Mtb. Can these opposing dynamics be reconciled? This evidence concerns the gene SLC16A1 and tuberculosis.