LEPR and clostridium difficile infection: We have previously demonstrated that host genetic make-up impacts CDI-induced tissue neutrophilia: homozygosity for a common single nucleotide polymorphism (SNP) in leptin receptor (LEPR), rs1137101, that results in a change of amino acid at position 223 of LEPR from Glutamine [Q] to Arginine [R] (Duggal et al., 2011), is also associated with an over-exuberant neutrophil response (Jose et al., 2018a).