Interestingly, incubation of rSj-Cys with BMDMs even inhibited the secretion of LPS-induced pro-inflammatory cytokines IFN-gamma and IL-6, and the addition of LPS could not prevent rSj-Cys-treated BMDMs from the secretion of IL-10 and TGF-β, (Figure 3), indicating rSj-Cys is able to inhibit bacterial infection-induced inflammation. This evidence concerns the gene TGFB1 and bacterial infectious disease.