Such short linear motifs in the intrinsically disordered C-terminal region, including the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif and the CagA multimerization (CM) motif, are essential for the biological activity of CagA as an oncogenic virulence factor that promotes the transformation of gastric epithelial cells into gastric cancer cells (Nishikawa et al., 2016). The gene discussed is S100A8; the disease is gastric cancer.