The oral microbiome is also related to various forms of metabolic dysbiosis, such as diabetes, hyperglycemia, and obesity (Saeb et al., 2019; De Andrade et al., 2020; Wei et al., 2020). Diabetes is reported to cause a shift in the oral microbiome with 16S rRNA sequencing and the reason for this shift may be enhanced expression of interleukin-17 in diabetes (Xiao et al., 2017). This evidence concerns the gene IL17A and diabetes mellitus.