INS and endocrine system disorder: Thyroid disease and diabetes mellitus are the two major endocrine disorders that are treated concurrently nowadays (Waring et al., 2012), so it is not surprising that TH and insulin signaling are related to each other. In the present study, several biochemical variables were demonstrated to differ significantly once serum TSH levels were beyond the normal range, which were mainly clinical indicators of glucose metabolism (including FSI, HOMA-IR, and HbA1C) and lipid metabolism (TC and TG).