Although previous studies in allergic asthma have conflicting results (Kool et al., 2011; Marichal et al., 2011; Allen et al., 2012), the pathological role of NLRP3 in airway neutrophilic inflammation is supported in a toluene diisocyanate (TDI)-induced asthma model recently (Chen et al., 2019). The gene discussed is NLRP3; the disease is asthma.