IL22 and type 2 diabetes mellitus: In another study, IL-22 is mainly produced by two subsets of ILCs, lymphoid tissue inducer (LTi) cells (50%) and NCR+ ILC3s (18%), and is significantly reduced in Mtb-infected mice with type 2 diabetes mellitus (T2DM) than in Mtb-infected mice without T2DM (Tripathi et al., 2019).