The lncRNA ST3Gal6 antisense 1 (ST3Gal6-AS1) is derived from the promoter region of gene encoding sialyltransferase ST3Gal6, and it mediates α-2,3 sialylation through the ST3Gal6-AS1/ST3Gal6 axis, thereby regulating PI3K/Akt signaling and leading to the nuclear translocation of Foxo1 in CRC cells (87). The gene discussed is AKT1; the disease is colorectal carcinoma.