An EBV antigen-based scramble-antigen vaccine (SAVINE) incorporating random overlapping peptide sets from EBNA1, LMP1 & LMP2 activated all immune cells including Th1 cells and CTLs against these three viral latent proteins. This vaccine also activated LMP1 & LMP2 responses in healthy individuals & NPC patients. Here, PSMB9 is linked to nasopharyngeal carcinoma.