Dual-targeting peptide-guided approach for precision delivery & cancer monitoring by using a safe upconversion nanoplatform. Targeting LMP1 assisted in vivo drug delivery & in vitro cellular uptake, contributing to tumor-specificity. The presence of pH-sensitive and cleavable linker contributes to EBNA1-LMP1 binding peptides release from the nanoparticles in acidic pH recapitulating the tumor microenvironment. This evidence concerns the gene PDLIM7 and cancer.