The currently available EBV epigenetic studies convincingly suggested that EBV utilizes different mechanisms to hijack the host epigenetic system in different tissue types, highlighting the critical role of EBV latent proteins LMP1, LMP2A, and EBNA3C in NPC, EBVaGC, and EBV-associated lymphomas, respectively. This evidence concerns the gene PDLIM7 and nasopharyngeal carcinoma.