As listed in Supplementary Table 1, 21 USPs were significantly correlated with poor overall survival of the HCC patients, including USP1, USP10, USP11, USP13, USP14, USP15, USP19, USP21, USP22, USP24, USP28, USP29, USP32, USP33, USP36, USP37, USP39, USP42, USP46, USP48, and USP54. Here, USP22 is linked to hepatocellular carcinoma.