As listed in Supplementary Table 1, 21 USPs were significantly correlated with poor overall survival of the HCC patients, including USP1, USP10, USP11, USP13, USP14, USP15, USP19, USP21, USP22, USP24, USP28, USP29, USP32, USP33, USP36, USP37, USP39, USP42, USP46, USP48, and USP54. The gene discussed is USP21; the disease is hepatocellular carcinoma.