As listed in Supplementary Table 1, 21 USPs were significantly correlated with poor overall survival of the HCC patients, including USP1, USP10, USP11, USP13, USP14, USP15, USP19, USP21, USP22, USP24, USP28, USP29, USP32, USP33, USP36, USP37, USP39, USP42, USP46, USP48, and USP54. This evidence concerns the gene USP39 and hepatocellular carcinoma.