Interestingly, some well-known HCC-related pathways were correlated with the high-risk score, including cell cycle, DNA replication, ERBB signaling, MYC signaling, G2/M checkpoints, PI3K/AKT/mTOR signaling, Wnt/β-catenin pathway, autophagy, and E2F signaling. This evidence concerns the gene MTOR and hepatocellular carcinoma.