This indicates that the use of tamsulosin and low-dose sildenafil to treat LUTS following brachytherapy leads to LUTS improvement (59).The mechanism of cell death induced by the treatment with sildenafil and DOX in PCa cells involves increased surface localization of CD95 (Fas receptor or APO-is a dead receptor) in the membrane, with concomitant inactivation of NF-κB and suppression of FLIP (inhibitory protein that blocks TRAIL-mediated cell dead) and FAP-1 (Fas-associated phosphatase-1, negative regulator of Fas) expression. Here, FAS is linked to posterior cortical atrophy.