HMGCR and cancer: On the other hand, as deeply discussed in a later section of the present review, it has been reported that HMGCR inhibitors (i.e., simvastatin) are able to overcome resistance or to potentiate the antitumoral effects of conventional chemotherapy in several models of cancer (in vitro and in vivo), such as, non-small cell lung cancer (183), resistant colorectal tumors (184) and human gastric cancer (39, 185).