Loss-of-function of tumor suppressor protein p53 (TP53) (86, 87) and cyclin-dependent kinases (cdks)- retinoblastome suppressor protein (Rb)- transcription factor E2F Transcription Factor 1 (E2F1) pathway (88–90), novel regulators of metabolism, promotes the acquisition and maintenance of glucose and/or lipid metabolism reprogramming phenotype in cancer. This evidence concerns the gene TP53 and cancer.