Analysis of expression of CD274 (PD-L1) (Figure 2C) and PDCD1LG2 (PD-L2) (Figure 2D) is shown with respect to stage - there was a significant increase in PD-L1 (CD274) expression associated with increased tumor stage (pT1-T2+ p=0.0031, pTa-T2+ p=<0.0001; one-way ANOVA with Tukey’s multiple comparison). The gene discussed is CD274; the disease is neoplasm.