In human chronic myeloid leukemia (CML) cells, co-treatment with spautin-1 and imatinib, a BCR-ABL tyrosine kinase inhibitor, potentiated imatinib-induced CML cell apoptosis in both the K562 cell line and primary cells (54). This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.