CD274 and myelodysplastic syndrome: For instance, depletion of M-MDSCs was relatively higher than G-MDSCs depletion in AML mouse model (C1498 in C57Bl/6J mice) treated with cytosine arabinoside (AraC) monotherapy or combination of AraC with Plerixafor (an immunostimulant to direct HSCs into peripheral circulation) and anti-PD-L1 mAb (76), while higher M-MDSCs frequency was observed in both low- and high-risk MDS compared with normal individuals (123).