CD8A and neoplasm: MDSCs suppress anti-tumor responses through multiple mechanisms including depletion of amino acids required for T cell proliferation (110), generation of reactive oxygen species (ROS) that alters T cell receptor and CD8 molecules leading to T cell tolerance (111), antigen presentation to induce Treg cells activities, and the production of anti-inflammatory cytokines such as TGF-β and IL-10 (112).