However in AML patients, increased expression of inhibitory receptors such as PD-1 and TIM3 have only been observed in relapsed or patients unresponsive to chemotherapy (56), and increased frequencies of PD-1+TIGIT+CD226−CD8+ T cells were associated with failure to achieve remission after induction chemotherapy (57). The gene discussed is TIGIT; the disease is acute myeloid leukemia.