Two patterns significantly associated with cancer staging were observed: a decreased expression level of RBM15B in breast invasive carcinoma (BRCA) and ZC3H13 in KIRC was accompanied by the progression of cancer stages, while YTHDF1 in liver hepatocellular carcinoma (LIHC) and IGF2BP3 in kidney renal papillary cell carcinoma (KIRP) showed the increased expression pattern (Figure 1C). This evidence concerns the gene IGF2BP3 and cancer.