Here we reported the altered expression of RNA m6A regulators across 13 cancer types in comparison with normal samples, revealing two rules in expression dynamics: the expression of “reader” proteins IGF2BP family and YTHDF family were up-regulated in most cancers, while methyltransferase METTL14, demethylase FTO and ALKBH5 were down-regulated in most cancers. This evidence concerns the gene MBD2 and cancer.