A HIF-2α-mediated activation of the EGFR signaling pathway including PI3K/AKT by hypoxia was also described by Wang and Schneider (34) in 2 out of 5 EGFR-overexpressing HNSCC cell lines in vitro and within hypoxic foci in human HNSCC tumors. This evidence concerns the gene AKT1 and head and neck squamous cell carcinoma.