We further investigated the role of LRIG3 in regulating the angiogenesis of glioma in vivo using intradermal angiogenesis assays and found that U87 cells stably overexpressing LRIG3 exhibited a significantly lower number of tumor-directed capillaries relative to cells transfected with the control vector (Figures 3A, B). This evidence concerns the gene LRIG3 and neoplasm.