Apparently, AP-2α can promote apoptosis via interaction with MYC gene based on breast cancer data (55) while AP-2γ is able to downregulate Growth Arrest and DNA-Damage-inducible Beta (GADD45B) and Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) in lung cancer e.g. to hinder programmed cell death (25). This evidence concerns the gene GADD45B and lung cancer.