Namely, AP-2γ may enhance EMT through increased Transforming Growth Factor Beta Receptor 1 (TGFBR1) expression which induces p21(RAC1)-Activated Kinase 1 (PAK1) phosphorylation and subsequent Mitogen-Activated Protein Kinase (MAPK) signaling (62) – this is meaningful for BLCA since PAK1 has been related to metastasis and invasion of bladder cancer (71) and MAPK network is itself important in this tumor (72). This evidence concerns the gene WNK2 and neoplasm.