Exemplary scenario based on breast cancer study suggests that it might be explained by WWOX ability to regulate Erb-B2 Receptor Tyrosine Kinase 4 (ErbB4) localization and stability: instead of ErbB4 Intracellular C-terminal Domain (ICD) translocation to the nucleus (which leads to increase in proliferation (51)), full-length receptor is stabilized by WWOX at the cell membrane (9). This evidence concerns the gene WWOX and breast cancer.