Literature data report that restoration of WWOX expression in osteosarcoma affects e.g. cell motility and that endogenous loss of this gene results in an elevation of Runt-related transcription factor 2 (RUNX2) level, ultimately revealing that direct WWOX-RUNX2 interaction via first WW domain of WWOX inhibits RUNX2 function (84, 85). Here, RUNX2 is linked to osteosarcoma.