Although these findings cannot be directly compared with previous studies, it has been found that via Rho GTPase 3 (RND3), AP-2γ regulates extracellular matrix anisotropy i.e. a pathological process of matrix remodeling which occurs during carcinogenesis and where fibronectin is partially implicated (57), indicating its role in generating invasion tracks for cancer cells. Here, FN1 is linked to cancer.