Furthermore, AP-2α viability-suppressing properties were described in hepatocellular carcinoma in case of which cancer cells survival was suppressed via inhibition of Extracellular-signal-Regulated Kinase (ERK), c-Myc and CyclinD1 (CCND1) in Ras-Raf-MEK-ERK pathway (45). This evidence concerns the gene MAP2K7 and hepatocellular carcinoma.