TNF and familial pancreatic carcinoma: Similar observations were noticed following WWOX overexpression in colon cancer (41) but also prostate, lung and pancreatic cancers (42), which might be due to enhancement of Tumor Necrosis Factor α (TNFα) cytotoxic function by WWOX (43) where it was confirmed that Reactive Oxygen Species (ROS) are the principal effectors of TNFα-mediated cell death (44).