Similarly, the chemical inhibition of CYP4A (Cytochrome P450 4A) in TAM in mouse models of breast cancer skewed their phenotype away from M2-like, and decreased the recruitment of VEGFR1+ myeloid cells and the expression of fibronectin by fibroblasts, altogether contributing to the metastatic process (21). This evidence concerns the gene FN1 and breast carcinoma.