TNF and neoplasm: TAMs with a “M1-like” phenotype are characterized by tumor-killing functions, inflammatory cytokines production such as TNFα, IL-1β, IL-6, and IL-8, nitric oxide (NO) and reactive oxygen species (ROS), as well as improved priming capacities towards T cells via upregulated MHC class I and II presentation and associated co-stimulatory molecules (17).