In non-small cell lung cancer, the concomitant tissue detection and quantification of macrophages and osteopontin revealed that osteopontin produced by TAM is also associated with progression and poor survival (77) and in colorectal cancer co-culture models, the expression by cancer cells of osteopontin receptor CD44 drives its production by TAM, which in turn favors tumor cells tumorogenicity (78). Here, SPP1 is linked to cancer.