circ-CUX1 knock-down inhibits aerobic glycolysis, proliferation, progression, and aggressiveness of NB. circ-CUX1 binds to EWSR1 to enable its contact with MAZ, leading to transactivation of MAZ and transcriptional modification of CUX1 and other genes linked with cancer progression. The gene discussed is EWSR1; the disease is neuroblastoma.