For example, based on KC mice, further depletion of the tumor suppressor high mobility group box 1 (HMGB1, Pdx1-Cre;KrasG12D;Hmgb1-/-) (69) or overexpression of tumor protein p53 (TP53) mutation (Pdx1-Cre;KrasG12D;Tp53R172H, termed KPC mice) (70) can significantly promote the development of KRAS-driven PDAC. Here, HMGB1 is linked to keratoconus.