However, depletion of mitophagy regulators, including PINK1 [Pdx1-Cre;KrasG12D;Pink1-/-] (22), PRKN [Pdx1-Cre;KrasG12D;Prkn-/-] (22), or BNIP3L/NIX [Pdx1-Cre;KrasG12D;Bnip3l-/- or Pdx1-Cre;KrasG12D;Tp53R172H; Bnip3l-/- (68), in KC mice exhibits different phenotype in pancreatic tumorigenesis. This evidence concerns the gene PRKN and keratoconus.