Given that ErbB3 activation induced by heregulin is previously described as a CTX-resistance mechanism, the combination of Patritumab (U3-1287), an anti-HER3 monoclonal antibody, and CTX with platinum-based therapy was evaluated in a randomized, double-blind, phase-II study of first-line treatment of patients with recurrent or metastatic HNSCC (NCT02633800) (158). Here, ERBB3 is linked to head and neck squamous cell carcinoma.