Unfortunately, by inducing immunosuppressive cytokines, apoptosis resistance, and EMT, the TLR4 signaling pathway can promote cancer cells’ immune escape in several cancer types (including lung, pancreas, and ovarian cancers, HNSCC) as well as resistance to therapy (paclitaxel in ovarian cancer) (209–212). This evidence concerns the gene TLR4 and ovarian carcinoma.