TLR4 activation induced activation of NF-κB and MAPK signaling pathways, resulting in the release of proinflammatory cytokines (TNF-α, iNOS, COX2, PGE2, NO) favoring EGFR permanent activation as well as the release of anti-apoptosis proteins (Bcl-2, Bcl-xl) allowing tumor cell survival. Here, EGFR is linked to neoplasm.