PLD1 and cancer: The most important enzymes in lipid metabolism, such as Acetyl-CoA Carboxylase (ACC), Fatty Acid Synthase (FASN), ATP Citrate Lyase (ACLY), Phospholipase D1 (PLD1), Stearoyl-CoA Desaturases 1 (SCD1), are closely related to cancer metastasis (11).