PSMC2 and cirrhosis of liver: In the multivariate Cox regression model, our data further confirmed that PSMC2 expression remained an independent significant prognostic biomarker for OS (P = 0.011, hazard ratio (HR) = 1.687, 95% confidence interval (CI) = 1.130-2.521) and DFS (P = 0.034, HR = 1.541, 95% CI = 1.033–2.299) for HCC patients after adjusting for age, sex, tumor size, tumor differentiation, TNM stage, and liver cirrhosis (Table 3).