FOXA2 and breast cancer: Interestingly, as a protein interacting with FOXA2, FOXP2 showed the highest correlation with FOXA2 in the basal subtype (see Figures 1H, I), which was the most lethal subtype with a high degree of metastasis ability associated with mesenchymal characteristics (54), implicating that the two proteins played important roles together in this subtype of breast cancer.