In univariate analysis, factors associated with poor progression-free survival were: Poor performance status (p < 0.001), higher age (p < 0.001), corticosteroid use at start of concomitant treatment (p < 0.001), un-methylated MGMT (p<0.001), secondary glioblastoma (p < 0.001), multifocal disease (p < 0.001), biopsy compared to resection (p < 0.001), and extent of resection defined by post-operative MRI (p = 0.002) and by the surgeon (p < 0.001). This evidence concerns the gene MGMT and glioblastoma.