HSPA8 and breast carcinoma: So, it can be speculated that if the interaction between DNAJC12 and Hsc70 in breast carcinoma cells is the same as that in LNCaP cells, DNAJC12 is bound to Hsc70, and the CHIP structure of Hsc70 is used to inhibit the expression of ESR1 protein, thus inhibiting the gene transcription mediated by ESR1.