The results showed that the activities of HDAC1, HDAC2, and HDAC3 in HCC tissues were significantly higher than those in adjacent tissues (Figure 2B). The results showed that the activities of HDAC2, HDAC1, and HDAC3 in HepG2 and MHCC97H cells were higher than those in other cells (Figure 2C, Supplementary Figures 1A, B). The gene discussed is HDAC1; the disease is hepatocellular carcinoma.