MIR22HG knockout antagonized the radiosensitization effect of Santacruzamate A (Figure 4A). The results of the wound healing assay showed that C646 can reduce the inhibitory effect of radiation in the migration ability of HCC cells, and Santacruzamate A can increase the inhibitory effect of radiation in the migration ability of HCC cells. This evidence concerns the gene MIR22HG and hepatocellular carcinoma.