Signaling pathways linked to EGF-EGFR in concert with CXCL5 regulate development of HCC (91), while the CXCL5-CXCR2 axis contributes to EMT of HCC cells via PI3K/Akt/GSK-3β/Snail signaling (92). This evidence concerns the gene AKT1 and hepatocellular carcinoma.