MBL rs7096206 polymorphism was associated with polymorphisms in VDR/VEGF and IL-18 which collectively conferred susceptibility to HCC in Asian populations (246), while MBL2 polymorphisms tended to influence the outcomes of HCC susceptibility, progressive tumor development, and clinical outcomes in patients infected with HBV (247). This evidence concerns the gene IL18 and hepatocellular carcinoma.