The relevance of the complement system is further underscored by its ability to principally regulate the cellular and molecular events in HCC including TAMs, TANs, Tregs, MDSCs, DCs, NK cells, and cytokine (IL-1, IL-2, TNF-α, IL-4, IL-10, etc.)and chemokine axes (CXCL12–CXCR4, CCL2–CCR2, etc). Here, CXCR4 is linked to hepatocellular carcinoma.