The relevance of the complement system is further underscored by its ability to principally regulate the cellular and molecular events in HCC including TAMs, TANs, Tregs, MDSCs, DCs, NK cells, and cytokine (IL-1, IL-2, TNF-α, IL-4, IL-10, etc.)and chemokine axes (CXCL12–CXCR4, CCL2–CCR2, etc). The gene discussed is IL2; the disease is hepatocellular carcinoma.