analyzed genetic polymorphisms and found that two SNPs in CR1 gene (rs3811381 and rs2274567) can potentially predispose subgroups of males, alcohol drinkers, and nonsmokers to HBV-HCC and HBV-chronic hepatitis B risks, while decreasing the risk to HBV-liver cirrhosis in females (231). The gene discussed is CR1; the disease is cirrhosis of liver.