<h4>Background</h4>Studies on the prognostic value of the soluble programmed death ligand 1 (sPD-L1) in cancer patients have not yielded consistent results.<h4>Objective</h4>This meta-analysis was performed to assess the association between sPD-L1 and the prognosis of cancer patients.<h4>Methods</h4>Published articles in Pubmed, EMBASE, and Cochrane clinical trial databases were searched from the inception to September 2020. This evidence concerns the gene SPDL1 and cancer.