To confirm the importance of the PI3K/AKT signaling pathway in regulating DcR3 expression in CRC after changes in TIPE, we stimulated TIPE-overexpressing HCT116 colon cancer cells with LPS and found increased phosphorylation levels of AKT, P105, and p65 and NF-κB activation. The gene discussed is TNFRSF6B; the disease is colonic neoplasm.