To investigate the role of TIPE and DcR3 in human CRC, we first analyzed the available datasets of CRC patients in the Cancer Genome Atlas (TCGA) database, and the differential expression of TIPE and DcR3 in CRC tissues and adjacent tissues was randomly validated with Gene Expression Profiling Interactive Analysis (GEPIA; http://gepia.cancer-pku.cn/index.html). The gene discussed is TNFRSF6B; the disease is colorectal carcinoma.