We also evaluated whether these core genes have significant differences in different molecular subtypes through performing differential analysis of the transcriptome expression data between LGGs and GBMs without IDH mutation or without 1p/19q deletion, and we found that between IDH wild-type TCGA-LGG and TCGA-GBM samples, 8 genes (GABRD, KCNA1, SYT1, CACNG3, OPALIN, HPCAL4, and KIF5A) showed differential expression patterns (Supplemental Figure 2B). The gene discussed is OPALIN; the disease is glioblastoma.