We would address the following questions: (1) whether miR-137 acts as a tumor suppressor to affect cell invasion and EMT in GBM cells with TMZ treatment, (2) whether LRP6 is the direct target of miR-137, (3) whether miR-137/LRP6 is involved in regulating cell proliferation, apoptosis, invasion, and the expression levels of EMT-related genes in GBM, associated with TMZ chemosensitivity, (4) whether miR-137/LRP6 inhibits the tumor growth in vivo, (5) how the hypoxia regulated miR-137 expression. This evidence concerns the gene LRP6 and glioblastoma.