In different tumor types, it either boosts tumor cell progression through triggering ubiquitination and degradation of tumor suppressors [e.g., Type Iγ phosphatidylinositol phosphate kinase (PIPKIγ), DAB2IP] or induces apoptosis by promoting the abundance of corresponding factors (e.g., Nur77, RhoA) (Figure 1). The gene discussed is NR4A1; the disease is neoplasm.