For example, phosphorylation of Smurf1 on Thr145 is not important for DAB2IP binding, Smurf1-mediated degradation of DAB2IP, or modulation of Smad1, but it does cause Smurf1 abundance and structural stability, which further increases the degradation of DAB2IP, resulting in tumor progression (16). This evidence concerns the gene DAB2IP and neoplasm.