For example, phosphorylation of Smurf1 on Thr145 is not important for DAB2IP binding, Smurf1-mediated degradation of DAB2IP, or modulation of Smad1, but it does cause Smurf1 abundance and structural stability, which further increases the degradation of DAB2IP, resulting in tumor progression (16). The gene discussed is SMURF1; the disease is neoplasm.