CD274 and renal cell carcinoma: Furthermore, exposure to broad-spectrum combination antibiotics (fluoroquinolones, ß-lactam+/- or macrolides) during anti-PD1/PD-L1 treatment has been shown to significantly decrease progression-free survival (PFS) and OS of patients with advanced non-small cell lung, renal cell carcinoma, and urothelial carcinoma, suggesting that the overall diversity of the microbiota and the presence of specific clades determines the responsiveness to immunotherapy (104).