Clinically, breast tumors are categorized into hormone receptor positive (HR+) tumors expressing the estrogen (ER) and/or progesterone (PR) receptors, Human Epidermal Receptor 2 (Her2)-enriched tumors with overexpression of Her2 in the absence of HR expression, and triple negative tumors lacking expression of all three receptors. The gene discussed is NR4A1; the disease is breast neoplasm.