Results have shown that these genes were highly expressed in BC tissue, these results indicated that the selected key genes may become therapeutic targets of BC, to be noted, PIMREG, MTFR2 were shown to have higher expression in TNM stage II compared with stage III, this indicate that the selection of preferable timing is rather crucial, for both the stemness of the tumor cells and immune infiltration characters of tumor tissue are in the phases of competition. The gene discussed is PIMREG; the disease is breast cancer.