CD274 and central nervous system cancer: CEP55 protein is required for membrane fusion of cytokinesis through the inhibitory of cyclin-dependent kinase 1 phosphorylation (36, 37), CEP55 was found to inhibit apoptosis of human glioma cells via the PI3K/Akt signaling pathway, the PI3K/Akt pathway is a crucial pathway in the immune escape, it promotes the progression of BC growth by suppressing NK cell cytotoxicity through eIF2b (38), also, the inhibition of PI3K in lung cancer downregulated PD-L1 expression (39).