GAL and hepatocellular carcinoma: Inspired by our previous report, a fusogenic lipid, consisting of 1,2‐dioleoyl‐sn‐glycero‐3‐phosphoethanolamine (DOPE), cholesteryl hemisuccinate (CHEMS) and distearoyl phosphoethanolamine–polyethylene glycol (DSPE‐PEG)‐galactose was used to enable the formation of lipopolyplex with stealth properties, HCC‐targeting ability and membrane fusion feature.[9, 12] After decoration with a sorafenib‐loaded lipid layer, the zeta potential of Gal‐SLPs decreased to ‐5.6 ± 0.8 mV and the size increased to 95.6±5.2 nm (Figure 1g–h).