In fact, inflammatory cytokines play essential roles in the initiation and maintenance of cellular senescence.[19] Based on the analysis of inflammatory cytokines involved in senescence, robust upregulation of IFN‐I and activation of its downstream Janus kinase‐signal transducers and activators of transcription (JAK‐STAT) signaling were observed in VSMCs of CKD/ApoE−/− mice (Figure 3B). Here, APOE is linked to chronic kidney disease.