As reported, defective mitochondrial fission or mitophagy‐induced accumulation of damaged mitochondria and other inflammatory responses can also affect VSMC senescence and phenotypic plasticity.[41, 42, 43] Of note, in our microarray data, we found that other inflammatory cytokines, including tumor necrosis factor and interleukin 1β, were also upregulated, but to a lesser extent, in the VSMCs of CKD/ApoE−/‐ mice (Figure 3C). Here, APOE is linked to chronic kidney disease.