Indeed, after 12 weeks of WD feeding, the plaque and necrotic core were larger, the fibrous cap was thinner, and the incidences of plaque hemorrhage and myocardial infarction were higher in CKD/ApoE−/‐ mice, indicating that CKD/ApoE−/‐ mouse was a useful mouse model for the investigation of the plaque vulnerability. This evidence concerns the gene APOE and chronic kidney disease.