Contemporarily, in an era of improved control of traditional risk factors, endothelial erosion appears to account for as high as one‐third of acute coronary syndromes.[30] As reported, IFN‐I and the downstream JAK‐STAT1 signaling directly induce EC dysfunction.[31, 32] Moreover, CKD is closely associated with EC dysfunction.[33] In the uremic milieu, IFN‐I response may also induce endothelial erosion and contribute to the increased risk of cardiovascular events in patients with CKD. This evidence concerns the gene STAT1 and chronic kidney disease.