We first immunoprecipitated Flag‐tagged cGAS in CKD serum‐incubated hVSMCs to detect coprecipitated DNA fragments, and observed significant enrichment for mitochondrial DNA (mtDNA), such as NADH dehydrogenases (ND1, ND2, ND4, ND5), but not nuclear DNA (nDNA), including DNA polymerase gamma, β‐actin, glyceraldehyde‐3‐phosphate dehydrogenase, and β2 microglobulin (B2M) (Figure 6C,D). Here, B2M is linked to chronic kidney disease.