APOE and chronic kidney disease: Meanwhile, the key molecules related to mitochondrial fission, such as dynamin 1‐like, as well as, mitophagy, such as PTEN‐induced putative kinase protein 1, voltage‐dependent anion channel 1, and sequestosome 1, were also downregulated in the VSMCs of CKD/ApoE−/‐ mice (GEO accession GSE135626).