APOE and chronic kidney disease: In this study, we found that there were no significant differences in serum cholesterol levels between AS and CKD/ApoE−/− mice, even after genetic invalidation or pharmacological inhibition of IFN‐I response (Figures S10G and S13F, Supporting Information), indicating that abnormal cholesterol metabolism might not be the main contributor to CKD‐associated aggravation of VSMC senescence and phenotypic switching.