DNA released from nuclear or mitochondria is the main source of endogenous DNA that activates cGAS‐STING pathway.[22] We observed obvious colocalization of DNA with cGAS in the fibrous cap VSMCs of Sham/ApoE−/− mice and the colocalization was much more frequent in CKD/ApoE−/− mice (Figure 6A). This evidence concerns the gene APOE and chronic kidney disease.