APOE and chronic kidney disease: We found that VSMCs from CKD/ApoE−/− mice displayed markedly reduced proliferation compared with those from Sham/ApoE−/− mice (Figure 2D,E), while the apoptosis level in the fibrous cap was comparable between Sham/ApoE−/− and CKD/ApoE−/− mice (Figure S2B, Supporting Information).