Notably, the gel contraction assays, as carried out here, are commonly used by researchers to study ECM remodeling in HCC,[26, 27] where an increase in gel contraction demonstrates a profibrotic feature.[28] Consistently, when HCC patient‐derived 3D organoids[29, 30, 31] or HCC cells were treated with increasing amounts of recombinant THBS2 (0, 50, 100, and 200 ng mL−1), a stepwise reduction in matrix gel, which corresponded to enhanced stiffness, was observed (Figure 3B). The gene discussed is THBS2; the disease is hepatocellular carcinoma.