It functions as a potent inhibitor of tumor growth and angiogenesis in a number of cancers, by interacting with MMPs and matrix serine proteases such as plasminogen activator and is recognized as an important ECM‐modifying enzyme.[51, 52] Although the association between THBS2 and ECM modification has been established, the link between THBS2 and matrix stiffness/softness has never been explored and remains a point of novelty in our current work. This evidence concerns the gene THBS2 and cancer.