Of interest, THBS2 has been suggested to alter MMP2 by binding to it and directing it to scavenger receptors like LRP on cell surfaces, resulting in its clearance from the ECM.[25] In regard to regulation of THBS2, recent studies have shown THBS2 to be regulated by a number of microRNAs including miR‐744‐5p,[41] miR‐1246,[42] miR‐221‐3p,[43] and miR‐20a.[44] Of note, our group has previously reported CD133+ liver CSCs to preferentially express miR‐1246 in HCC;[45] but whether miR‐1246 targets THBS2 in HCC will need to be further explored. This evidence concerns the gene MMP2 and hepatocellular carcinoma.