THBS2 is also widely recognized as an ECM‐modifying enzyme.[22] Consistent with these THBS2 roles, we found that lentiviral‐based stable overexpression of THBS2 in HCC cells (Huh7, PLC8024, and MHCC97L) suppressed the activity levels of both MMP9 and MMP2 and led to the degradation of the ECM, as evidenced by gelatin zymography and degradation assays, respectively (Figure 1G,H). The gene discussed is THBS2; the disease is hepatocellular carcinoma.