THBS2 and hepatocellular carcinoma: To further demonstrate the link between THBS2, matrix stiffness, and aggressive cancer properties in HCC, we performed an in vivo orthotopic liver metastasis model in which we injected MHCC97L‐expressing HCC cells primed with a recombinant THBS2 (rTHBS2)‐modified matrix gel in vivo directly into the liver.