The rTHBS2 and 5‐FU combination treatment resulted in a marked reduction not only in tumor size and the number of lung metastatic nodules (Figure 4A) but also in CD133 expression, while enhancing collagen fiber deposition, as shown by Masson's trichrome staining (Figure 4B; Figure S6C, Supporting Information). This evidence concerns the gene PROM1 and neoplasm.