RAS GTPases, including HRAS, KRAS, and NRAS, are central hubs for transmitting signals from extracellular stimuli to the interior of the cell.[28] Once activated, RAS binds to and activates the RAF family kinases, which in turn initiate downstream signal transduction through a cascade of trans‐phosphorylation of MEK1/2 and ERK1/2.[21, 28] A growing body of evidence has demonstrated that the RAS‐associated signaling pathway is closely correlated with carcinogenesis by stimulating tumor cell growth, proliferation, and metastasis. This evidence concerns the gene MAP2K1 and neoplasm.