Accumulating evidence supports an association between dysregulated expression of TAK1 and many human diseases including cancer.[7, 9, 11, 13, 14, 15, 17] TAK1 was initially discovered as a protein that mediates TGFβ and bone morphogenetic protein signaling transduction.[31] Subsequent studies have shown that TAK1 plays a pivotal role in tumor microenvironment construction and thus affects cancer progression.[32] In this study, we compared the expression level of TAK1 between esophageal squamous tumor and normal tissues and found that TAK1 was expressed at lower levels in tumor tissues. Here, MAP3K7 is linked to neoplasm.