NUAK2 and anencephaly: Anencephaly is a form of NTD, which can be caused by a deleterious recessive mutation in NUAK2, serine/threonine kinase that results in impaired actomyosin contractility via the Hippo‐YAP pathway.[39] induced pluripotent cells (iPSCs) were derived from anencephalic non‐viable fetuses born to consanguineous parents bearing the NUAK2 deletion by Sendai virus reprogramming as previously reported[40] (Figure 6A and Figure S6, Supporting Information).