Functional impairment of ORAI1 or STIM1 deficiency causes severe combined immunodeficiency (SCID) in mouse models and human patients, and various functional problems have been reported (Prakriya & Lewis, 2015; Feske, Wulff & Skolnik, 2015; Nohara et al., 2015). This evidence concerns the gene ORAI1 and severe combined immunodeficiency.