INS and obesity due to melanocortin 4 receptor deficiency: M. funiformis and F. mortiferum belong to Gram-negative bacteria (Sakon et al., 2008), which their cell walls contain more lipopolysaccharides that can induce or aggravate the host to produce inflammatory response and insulin resistance, thus involving in the occurrence and development of obesity (Muscogiuri et al., 2019).