EPCAM and colorectal carcinoma: Taken together, the high expression of EpCAM in colon and rectum and low EMT in CRC might explain why EpCAM has the highest CTC detection rate in CRC (Tan et al., 2014; https://www.proteinatlas.org/ENSG00000119888-EPCAM/tissue; Spizzo et al., 2011).