NLRP3 and Parkinson disease: Attention has recently focused on the contribution of autophagy and the inflammation response to the pathogenesis of PD.8, 9, 10 Autophagy and inflammasome were activated during the progress of PD, and an effective control of the activation of autophagy and inflammasome was expected to be a new therapeutic target for PD.11, 12, 13 NALP3 and cell division protein kinase 5 (CDK5) were found to, respectively, participate in the regulation of autophagy and inflammasome in PD.11