IRS2 and cancer: ,80,81 miR-7 downregulates central oncogenic factors in cancer-related pathways such as EGF (epidermal growth factor) receptor, IRS-1 (insulin receptor substrate-1), IRS-2 (insulin receptor substrate-2), Pak1 (p21-activated kinase 1), and PIK3CD (phosphoinositide-3-kinase, catalytic, delta polypeptide), demonstrating that miR-7 exerts an important tumor-suppressive role via widespread regulatory control.7