In breast cancer tissue, circCCNB1 (circRNA cyclin B1) formed a complex with H2AX (histone family 2A variant) and Bclaf1 (B cell leukemia/lymphoma 2 apoptosis regulator-associated transcription factor 1) to induce cell death in p53 mutant cells.26 This evidence concerns the gene TP53 and breast carcinoma.