Overexpressed circPTK2 protected TIF1γ (transcriptional intermediary factor 1 gamma), an essential regulator of TGF-β signaling and EMT, by sponging miR-429/miR-200b-3p in NSCLC cells, culminating in the inhibition of EMT and tumor metastasis. Here, TRIM33 is linked to non-small cell lung carcinoma.