TRPM2 and Sepsis: For example, sphingosine 1-phosphate receptor (S1PR) family [20–23], triggering receptor expressed on myeloid cells (TREM) family [24, 25], ion channel P2X7 [26–28] and transient receptor potential melastatin 2 (TRPM2) [29–31], as well as the endoplasmic-reticulum resident transmembrane protein sigma-1 (σ1) receptor [32], have all been proven as pharmacologically acceptable targets with significant influence to sepsis pathophysiology and the final outcomes (Fig. 2) [33].